Professor, Department of Chemical & Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6393.
Tel: (610) 254-0960.
e-mail: shieh@seas.upenn.edu

EDUCATION.
Ph.D. (1977), M.S.E. (1975), Environmental/Chemical Engineering, University of Massachusetts at Amherst.
M.S.E. (1972), B.S.E. (1970), Civil Engineering, National Cheng Kung University, Tainan, Taiwan.

PROFESSIONAL EXPERIENCE.
Professor, Associate Professor, and Assistant Professor (1983 −), University of Pennsylvania.
Undergraduate Curriculum Chair (2003 − 2018), Department of Chemical and Biomolecular Engineering, University of Pennsylvania.
Visiting Professor (1996 − 1997), Department of Marine Environment, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Graduate Group Chair (1992 − 1996), Department of Systems Engineering, University of Pennsylvania.
Fulbright Professor (1988 − 1989), Institute of Water and Environmental Engineering, Tampere University of Technology, Tampere, Finland.
Visiting Professor (1982 − 1983), Department of Environmental Engineering, National Chung Hsin University, Taichung, Taiwan.
Project Engineer (1981 − 1983), Exxon Research and Engineering Company, Florham Park, New Jersey.
Process Engineer (1978 − 1981), Dorr-Oliver, Inc., Stamford, Connecticut.

HONORS AND AWARDS.
The S. Reid Warren, Jr. Award, University of Pennsylvania (2013).
Fulbright Professor Award, Institute of Water and Environmental Engineering, Tampere
University of Technology, Tampere, Finland (1988).
Visiting Expert Award, National Science Council, Republic of China (1982).
Member, the Phi Tau Phi Scholastic Honor Society, China (1972 −).
Graduate Fellowship (1973 − 1977), Massachusetts Water Resources Commission.
Graduate Fellowship (1970 − 1972), Ministry of Education, Republic of China.

NUMBER OF PUBLICATIONS: 136.

BIOENVIRONMENTAL/BIOCHEMICAL ENGINEERING−RELATED PUBLICATIONS (93).
Mathematical model of the anaerobic contact process. J. Chinese Instn. Hydr. Eng., 17, 24 –47 (1972) (with K.T. Tsai and C.F. Kao).
Effect of initial substrate concentration on the rte of nitrification in a batch experiment. Biotechnol. Bioeng., 21, 201 − 211 (1979) (with E.J. LaMotta).
Theoretical analysis of the effect of mass-transfer resistances on the Lineweaver−Burke plot. Biotechnol. Bioeng., 21, 503 − 504 (1979).
Diffusion and reaction in biological nitrification. J. Env. Eng Div., ASCE, 105, 655 – 673 (1979) (with E.J. LaMotta).
The intrinsic kinetics of nitrification in a continuous flow suspended growth reactor. Wat. Res., 13, 123 − 127 (1979) (with E.J. LaMotta)
Suggested kinetic model for the fluidized bed biofilm reactor. Biotechnol. Bioeng., 22, 667 − 676 (1980).
The effect of internal mass transfer resistances on the interpretation of substrate removal rate in the suspended growth system. Wat. Res., 14, 695 − 699 (1980).
Simplified mathematical models for a fluidized bed biofilin reactor. Water − 1980, AlChE
Symp. Series, 77, 273 − 285 (1981) (with L.T. Mulcahy and E.J. LaMotta).
Kinetic model of biological denitrification in a fluidized bed biofilm reactor. Prog. Wat. Tech., 12, 143 − 158 (1981) (with L.T. Mulcahy and E.J. LaMotta).
Discussion on fluidized bed for biological wastewater treatment. J. Env. Eng. Div., ASCE, 107, 293 − 296 (1981) (with L.T. Mulcahy).
Fluidized bed biofilm reactor effectiveness factor expressions. Trans. Instn. Chem. Eng., 59, 129 − 133 (1981) (with L.T. Mulcahy and E.J. LaMotta).
Comments on biologically active fluidized beds. Biotechnol. Bioeng., 23, 2145 − 2147 (1981).
Predicting reactor biomass concentration in a fluidized bed biofilm reactor. J. Wat. Pollut. Control Fed., 53, 1574 − 1584 (1981) (with P.M. Sutton and P. Kos).
Experimental determination of intrinsic denitrification kinetic constants. Biotechnol. Bioeng., 23, 2403 − 2406 (1981) (with L.T. Mulcahy and E.J. LaMotta).
Dorr-Oliver's Oxitron system fluidized bed wastewater treatment process. Biological Fluidized Bed Treatment of Water and Wastewater, 285 − 300, eds. P.F. Cooper and B. Atkinson, Ellis Horwood, Chichester, England (1981) (with P.M. Sutton, P. Kos, and P. Dunning).
Intrafloc mass tansfer effect on the Lineweaver-Burke Plot. Biotechnol. Bioeng., 24, 977 − 978 (1982).
Mass transfer in a rotating biological contactor. Wat. Res., 16, 1071− 1074 (1982).
A mathematical model for the fluidized bed biofilm reactor. Enzyme Microb. Technol., 4, 269 − 275 (1982) (with L.T. Mulcahy and E.J. LaMotta).
Preliminary study of a suspended growth predenitrification system. Biotechnol. Bioeng., 24, 2557 − 2572 (1982) (with C.Y. Chen and S.D. Chang).
FBBR kinetics − a rational design and optimization approach. Wat. Sci. Tech., 15, 321 − 332 (1983) (with L.T. Mulcahy).
Biomass hold-up correlations for a fluidized bed biofilm reactor. Chem. Eng. Res. Des., 62, 133 − 136 (1984) (with C. Y. Chen).
Biomass hold-up in a fluidized bed biofilm reactor. Proc. 2nd Int. Conf. on Fixed-Film Biological Processes, 191− 205 (1984) (with L.T. Mulcahy).
Waste treatment and methane production using the anaerobic fluidized bed system. Proc. 17th Mid-Atlantic Ind. Waste Conf., 6 − 13 (1985) (with J.D. Keenan and C.T. Li).
Experimental determination of intrinsic kinetic coefficients for biological wastewater treatment systems. Proc. Modeling of Biological Wastewater Treatment, 7 − 15 (1985)
(with L.T. Mulcahy).
Performance evaluation of the anaerobic fluidized bed System: I. substrate utilization and gas production. J. Chem. Tech. Biotechnol., 35B, 101 − 109 (1985) (with S.J. Chen and C.T. Li).
Performance evaluation of the anaerobic fluidized bed system: II. biomass inventory and characteristics. J. Chem. Tech. Biotechnol., 35B, 183 − 190 (1985) (with S.J. Chen and C.T. Li).
Performance evaluation of the anaerobic fluidized bed system: III. process kinetics. J. Chem. Tech. Biotechnol., 35B, 229 − 234 (1985) (with S.J. Chen and C.T. Li).
Microbial toxicity monitor for in situ continuous applications. Biotechnol. Bioeng., 27, 1500 − 1506 (1985) (with C.J. Yee).
PAC-activated sludge treatment of coke plant wastewater. Proc. 40th Purdue Ind. Waste Conf., 33− 41 (1986) (with Y.M. Chao).
Performance evaluation of the anaerobic fluidized bed biofilm reactor: methane recovery from glucose. Proc. 40th Purdue Ind. Waste Conf., 925 − 936 (1986) (with S.J. Chen and C.T. Li).
PAC/predenitrification activated sludge treatment of steel mill coke-plant wastewater. Proc. World Congress III of Chem. Eng., 584 − 588 (1986) (with D.J. Richards).
Performance evaluation of an anoxic/oxic activated sludge system: effects of mean cell residence time and anoxic hydraulic retention time. Biotechnol. Bioeng., 28, 7 − 15 (1986)(with C.Y. Chen).
Experimental determination of intrinsic kinetic coefficients for biological wastewater treatment. Wat. Sci. Tech., 18, 1 − 10 (1986) (with L.T. Mulcahy).
PAC-activated sludge treatment of a steel mill coke-plant wastewater. J. Wat. Pollut. Control Fed., 58, 333 − 339 (1986) (with Y.M. Chao and T.F. Yeh).
Evaluation of mass transfer effects in a biofilm reactor. J. Environ. Prot. Soc., 9, 50 − 60 (1986) (with C.Y. Chen).
Combined chemical/bio-fluidized bed treatment of slaughterhouse wastewater. J. Env. Eng. Div., ASCE, 112, 718 − 728 (1986) (with C.T. Li, C.S. Wu, and J.S. Huang).
Development of a microbial toxicity monitor. Toxicity Assessment, 1, 301 − 315 (1986) (with C.J. Yee).
Biological fate of organic priority pollutants in the aquatic environment. Wat. Res., 20, 1077 − 1090 (1986) (with D.J. Richards).
Fluidized bed biofilm reactor for wastewater treatment. Advances in Biochemical Engineering/Biotechnology, 33, 132 − 169, ed. A. Fiechter, Springer-Verlag, Berlin (1986)
(with J.D. Keenan).
Treatment of slaughterhouse wastewater using fluidized bed biofilm reactors. Proc. 13th IAWPRC Biennial Int. Conf., 1 − 10 (1987) (with C.T. Li, C.S. Wu, and J.S. Huang).
Fluidization and reactor biomass characteristics of the denitrification fluidized bed biofilm reactor. Wat. Res., 21, 451 − 458 (1987) (with L.T. Mulcahy).
Anoxic biofilm degradation of monocyclic aromatic compounds. Biotechnol. Bioeng., 30,1077 − 1083 (1987) (with L.Z. Hu).
Biofilm kinetics - mass transfer effects and their implications to process design, operation, and control. Bioenvironmental Systems, 4, 155 − 179, ed. D.L. Wise, CRC Press, Boca Raton, Florida (1987).
High-rate anaerobic treatment of industrial wastewater. Global Bioconversion, 3, 41 − 79, ed. D.L. Wise, CRC Press, Boca Raton, Florida (1987) (with A.Y. Li).
Treatment of slaughterhouse wastewater using fluidized bed biofilm reactors. Wat. Sci. Tech., 19, 1 − 10 (1987) (with C.T. Li, C.S. Wu, and J.S. Huang).
Anoxic/oxic activated sludge treatment kinetics of cyanides and phenols. J. Env. Eng. Div., ASCE, 114, 639 − 654 (1988) (with D.J. Richards).
Anaerobic fluidized bed treatment of a tannery wastewater. Chem. Eng. Res. Des., 66, 518 − 523 (1988) (with S.J. Chen and C.T. Li).
Anaerobic fluidized bed treatment of an industrial Wastewater. J. Wat. Pollut. Control. Fed., 60, 1826 − 1832 (1988) (with S.J. Chen and C.T. Li).
Anoxic/oxic activated sludge treatment of cyanides and phenols. Biotechnol. Bioeng., 33, 32 − 38 (1989) (with D.J. Richards).
Performance and kinetics of aerated fluidized bed biofilm reactor. J. Env. Eng. Div., ASCE, 115, 65 − 79 (1989) (with C.T. Li).
Immobilized-cell degradation of chlorophenols. J. Env. Eng. Div., ASCE, 116, 683 − 697 (1990) (with J.A. Puhakka, E. Melin, and T. Tuhkanen).
Continuous fermentation of ethanol from glucose using the biofluidized bed technology. J. Res. Mangt. Technol., 18, 79 − 83 (1990) (with E. Melin).
Oxic fluidized-bed treatment of dichlorophenols. Wat. Sci. Tech., 24, 171 − 177 (1991) (with J.A. Puhakka, E. Melin, K. Jarvinen, and T. Tuhkanen).
Anaerobic treatment of Kraft pulp-mill waste activated-sludge: gas production and solids reduction. Bioresource Technol., 39, 61 − 68 (1992) (with J.A. Puhakka and M. Alavakeri).
Anaerobic treatment of Kraft pulp-mill waste activated-sludge: sludge dewaterability and filtrate quality. Bioresource Technol., 39, 69 − 75 (1992) (with J.A. Puhakka and M.
Alavakeri).
Continuous ethanol fermentation using immobilized yeasts in a fluidized bed reactor. J. Chem. Tech. Biotechnol., 55, 339 − 346 (1992) (with V.T. Nguyen).
Effects of microcarrier pore characteristics on methanogenic fluidized bed performance. Wat. Res., 6, 1119 − 1125 (1992) (with C.J. Yee and Y. Hsu).
Continuous ethanol production from glucose using Saccharomyces cerevisiae immobilized on fluidized microcarriers. Chem. Eng. J., 50, B17 − B22 (1992) (with E. Melin).
Chlorophenol degradation under oxic and anoxic conditions. Wat. Sci. Tech., 25, 147 − 152 (1992) (with J.A. Puhakka, K. Jarvinen, and E. Melin).
The effects of fill strategies on SBR performance under nitrogen deficiency and rich conditions. Proc. 2nd Int. Specialized Conf. on Design and Operation of Small
Wastewater Treatment Plants, 407 − 414 (1993) (with R.E. Sheker and R.M. Aris).
Start-up of anaerobic fluidized bed reactors with acetic acid as the substrate. Biotechnol. Bioeng., 41, 347 − 353 (1993) (with Y. Hsu).
Degradation of 4-chlorophenol in denitrifying fluidized-bed process. J. Environ. Sci. Health, A28(8), 1801 − 1811 (1993) (with E. Melin and J.A. Puhakka).
The effects of fill strategies on SBR performance under nitrogen deficiency and rich conditions. Wat. Sci. Tech., 28, 259 − 266 (1993) (with R.E. Sheker and R.M. Aris).
Biological fluidized bed treatment of phenol and amines. Wat. Sci. Tech., 31, 185 − 193 (1995) (with V.T. Nguyen).
Fluidized-bed biofilms for chlorophenol mineralization. Wat. Sci. Tech., 31, 227 − 235 (1995)(with J.A. Puhakka and E. Melin).
Evaluation of intrinsic and inhibition kinetics in biological fluidized bed reactors. Wat. Res., 29, 2522 − 2526 (1995) (with V.T. Nguyen).
Biomass loss from an anaerobic fluidized bed reactor. Wat. Res., 30, 1253− 1257 (1996) (with Y. Hsu).
Batch monoethylamine degradation under nitrate respiration conditions. Wat. Res., 30, 2530 − 2534 (1996) (with B. Lai).
Substrate inhibition kinetics in a fluidized bioparticle. Chem. Eng. J., 65, 117 − 121 (1997) (with B. Lai).
Anaerobic fluidized bed pretreatment of a hog wastewater. J. Env. Eng. Div., ASCE, 123, 389 − 394 (1997) (with C.Y. Chen and C.T. Li).
Performance of anaerobic fluidized bed reactors during pseudo-steady-state operation. J. Chem. Technol. Biotechnol., 69, 45 − 57 (1997) (with M.H. El-Farhan, P.H. Chin Hong, and J.D. Keenan).
Secondary wastewater treatment. Environmental Engineers' Handbook, 683 − 732, ed. D. Liu, Lewis Publishers, Boca Raton, FL (1997) (with V.T. Nguyen).
Batch phenol degradation by Candida tropicalis and its fusant. Biotechnol. Bioeng., 60, 391 − 395 (1998) (with Y.H. Chang, C.T. Li, and M.C. Chang).
Biological fluidized bed treatment of ethylene and propylene glycols. Wat. Sci. Technol., 38, 145 − 153 (1998) (with J.A. Lepore and I. Zandi).
Overloading responses of a glucose-fed anaerobic fluidized bed reactor. Biochem. Eng. J., 3, 17 − 23 (1999) (with M.H. El-Farhan).
Anoxic/oxic biodegradation of aminobenzene. J. Env. Eng., ASCE, 125, 602 − 607 (1999) (with S.K. Tai).
Biodegradation of dispersed diesel fuel under high salinity conditions. Wat. Res., 34, 3303 − 3314 (2000) (with L. Yang and C.T. Lai).
An innovative aquaculture system. Proc. IWA − 2001 Berlin World Water Congress, 100 − 107 (2001).
Biofilter treatment of aquaculture water for reuseaApplications. Wat. Res., 35, 3097 − 3108 (2002) (with L. Yang and L.S. Chou).
Impulse responses of a monoethylamine-fed fluidized bed reactor. Wat. Res., 37, 2331 − 2338 (2003) (with Y. Tsao).
Analysis of immobilized cell responses to substrate impulses. Biochem. Eng. J., 18, 177 – 184 (2004) (with Y. Tsao).
Performance of an aerobic/anaerobic hybrid bioreactor under the nitrogen deficient and low F/M conditions. Wat. Res., 40, 1442 − 1448 (2006) (with C.M. Sales).
Sustainable aquaculture: the Penn process. Proc. 2nd Taiwan-Japan Seminar on Development and Management of Fisheries, 126 − 134 (2007).
Analysis of an upflow bioreactor system for nitrogen removal via autotrophic nitrification and denitrification. Bioresource Technol., 90, 6292 − 6298 (2008) (with K. Nootong).
Simultaneous autotrophic denitrification and nitrification in a low-oxygen reaction environment. Wat. Sci. Technol., 70(4), 729 − 735 (2014) (with G. Ramanathan and C.M.
Sales).
Cellulosic fermentation using the Bacillus thermoamylovorans-enabled digested sludge. J. Environ. Eng., ASCE. doi:10.1061/(ASCE)EE.1943-7870.0000990 (2015) (with C.L. Han and J. J. Lay).
A novel bioreactor for high density cultivation of diverse microbial communities. J. Vis. Exp., 106, e53443, doi:10.3791/53443 (2015) (with J. Price and C.M. Sales).
Untangling the microbial ecosystem and kinetics in a nitrogen removing photosynthetic high density bioreactor. Environ. Sci.: Water Res. Technol., doi: 10.1039/C6EW00078A (2016) (with J. Price and C.M. Sales).
Diesel degradation in soil catalyzed by the addition of a bioagent. Int. J. Environ. Sci. Technol., 13, 551 – 560 (2016) (with Y. Lin and J.J. Lay).
Anaerobic Biotechnology. To appear in Environmental Technology Review (2018).
Development of Bermuda grass (Cynodon dactylon) seedlings in the diesel−contaminated soil. Environmental Technology (under review) (with Y. Lin and J.J. Lay).
In−Vessel composting of acidified high−solids liquid wastes. Environmental Technology (under review) (with C.L. Han and J.J. Lay).
Bioagent−enhanced farming of Pacific white shrimps (Litopenaeus vannamei). Aquacultural Engineering (under review) (with C.L. Han and J.J. Lay).
Mass production of micro-algae in an upflow, photo−bioreactor: process efficiency and kinetics. Bioresource Technology (under review) (with C. Gill).

Ph.D./M.S.E. PRODUCTIVITY.
Ph.D.: 20.
M.S.E.: 45.
TEXTBOOKS UNDER PREPARATION (Publisher: Wiley & Sons, Inc.).
Engineering and the Environment (Publication Date: 2019).
Introductory Engineering Statistics (Publication Date: 2020).

RESEARCH FOCI.
Bioenvironmental Engineering: Development of biological engineering processes for environmental applications. Examples include biological fluidized bed reactors for surface and ground water decontaminations, sequencing batch reactors for nitrogen removal, and upflow, high density photo−bioreactors for micro−algae cultivation.
Biological Nitrogen Removal: Nitrogen removal via biologically-mediated pathways. Examples include simultaneous carbon and nitrogen removal in amines, autotrophic nitrification and denitrification (kinetics and mechanisms), synergetic bacterial-algal nitrogen removal, and biofilm nitrification−denitrification kinetics.
Environmental Biotechnology: Examples include biogas production from concentrated liquid waste streams with or without high−solid contents, mass cultivations of micro-algae for fatty acid/protein recoveries, and in situ bioremediation of hazardous compounds